Acitretin is the major metabolite of etretinate and is a retinoid used to treat psoriasis. Acitretin is a synthetic analog of retinoic acid, the main metabolite of etretinate, which has been used to treat psoriasis for years. The exact mechanism is not understood (2, 3). Retinoids have a similar structure to vitamin A and are involved in the normal growth of skin cells. Acitretin inhibits excessive cell growth and keratinization (thickening of skin cells due to protein deposition), and therefore, reduces the thickening of skin, plaque formation, and scaling seen in psoriasis. Acitretin is teratogenic in humans and is contraindicated in pregnancy. The duration of teratogenic risk is not known.

Why do you need a Acitretin monograph?

Superior Toxicology and Wellness’s monographs are a cost-effective and convenient way to meet the requirements for PDEs (ADEs)

  • The numerical OEL and control band assignment needed to determine the level of required engineering controls and personal protective equipment
  • A listing of all cited references utilized in the derivation of the OEL and ADE
  • An expert review and discussion with respect to the critical endpoints of concern, the rationale for the choice of endpoints, and dose that is to be used in the derivation of the ADE (PDE), as required by the EMA’s Guideline on setting health-based exposure limits for use in risk identification in the manufacture of different medicinal products in shared facilities

Benefits of Superior Toxicology and Wellness monographs:

  • Full drug documentation. The report consists of 10-12 pages in length, with calculations and cited references.
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