Adenosine is indicated for the treatment of periodic episodes of irregular heart rate and as a stress agent, during imaging procedures, to evaluate heart function and blood flow. Adenosine slows conduction of electric impulses through a portion of the heart and can restore normal sinus rhythm in patients with intermittent irregular heart beats. Adenosine, also, causes vessels to become larger, which increases blood flow to and in the heart. Adenosine is thought to exert this pharmacological effect through activation of purine receptors (cell-surface A1 and A2 adenosine receptors).
Why do you need a Adenosine monograph?
Superior Toxicology and Wellness’s monographs are a cost-effective and convenient way to meet the requirements for PDEs (ADEs)
- The numerical OEL and control band assignment needed to determine the level of required engineering controls and personal protective equipment
- A listing of all cited references utilized in the derivation of the OEL and ADE
- An expert review and discussion with respect to the critical endpoints of concern, the rationale for the choice of endpoints, and dose that is to be used in the derivation of the ADE (PDE), as required by the EMA’s Guideline on setting health-based exposure limits for use in risk identification in the manufacture of different medicinal products in shared facilities
Benefits of Superior Toxicology and Wellness monographs:
- Full drug documentation. The report consists of 10-12 pages in length, with calculations and cited references.
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