Agomelatine is indicated for use in the treatment of major depressive episodes in adults. Agomelatine is a melatonergic agonist (MT1 and MT2 receptors) and 5-HT2C antagonist. Binding studies indicate that agomelatine has no effect on monoamine uptake and no affinity for α, β adrenergic, histaminergic, cholinergic, dopaminergic, and benzodiazepine receptors. Agomelatine increases noradrenaline and dopamine release, specifically in the frontal cortex, and has no influence on the extracellular levels of serotonin. Agomelatine has also been shown to resynchronize circadian rhythms in animal models of circadian rhythm disruption.
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